Advances in Cancer Research, Vol. 49 by George Klein (ed.), Sidney Weinhouse (ed.) PDF

By George Klein (ed.), Sidney Weinhouse (ed.)

ISBN-10: 0120066491

ISBN-13: 9780120066490

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Natl. Acad. Sci. A. 74, 3399-3403. Adams, S. , Focht, R. , and Pacifici, M. (1982). Cell 30, 737-784. , and Boettiger, D. (1985a). Mol. Cell. Biol. 5, 538-544. , and Tat6, F. (1985b). Nature (London)316,557559. Anthony, D. , Schuetze, S. , and Rubin, L. L. (1984). Proc. Natl. Acad. Sci. A. 81,2265-2269. Barkas, A. , and Stavnezer, E. (1986). Virology 151, 131-138. , and Feramisco, J . (1985). Cell 42, 841-848. Bennett, G . , Fellini, S. , and Holtzer, H. Cell Biol. 82, 577584. , and Graf, T. (1980).

14. , 1985). Thus, the gag moiety of FBR-MSV can be removed without affecting its transforming potential. 15. The transformingfos proteins vary in size from 268 amino acids (FBJ/R) to 381 amino acids (FBJ), but they all have nuclear location. Additionally, all fos proteins coimmunoprecipitate a 39K cellular protein whose identify remains obscure. 16. , 1985). 17. , 1984). , 1984). The extent and precise nature of the fos protein modifications remain unknown, but part of the modifications is due to phosphorylation (J.

Structure of the fos Gene and Protein The complete nucleotide sequences of the FBJ-MSV and FBR-MSV proviral DNAs and the cellular progenitor of the fos gene were deter- 34 INDER M. VERMA AND W. , 1983, 1984). Figures 2 and 3 display the organization of the viral and cellular fos genes and their deduced products. The salient features can be summarized as follows: 1. FBJ-MSV proviral DNA contains 4,026 nucleotides, including two long terminal repeats (LTRs) of 617 nucleotides each, 1,639 nucleotides of acquired cellular sequences (v-fos), and a portion of the envelope (enu) gene.

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Advances in Cancer Research, Vol. 49 by George Klein (ed.), Sidney Weinhouse (ed.)


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