Get Advances in Immunology, Vol. 52 PDF

By Frank J. Dixon (Ed.)

ISBN-10: 0120224526

ISBN-13: 9780120224524

Meant for researchers in immunology, mobile biology, virology and drugs, this booklet presents info on such issues as cytokine gene law, and animal versions for received immunodeficiency syndrome.

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23 Activation of adaptive immunity in the draining lymph node. Pathogens, pathogen components, and dendritic cells carrying pathogens and molecules derived from them arrive in the afferent lymph draining the site of infection. Free pathogens and debris are removed by macrophages; the dendritic cells become resident in the lymph node and move to the T-cell areas, where they meet small lymphocytes that have entered the node from the blood (green). The dendritic cells specifically stimulate the division and differentiation of pathogen-specific small lymphocytes into effector lymphocytes (blue).

Both follicle and PALS are surrounded by a perifollicular zone abutting the red pulp and containing a variety of cells, including erythrocytes, macrophages, T cells, and B cells. Photographs courtesy Yasodha Natkunam. 25 Diagnosis of a child with asplenia. The photos show scintillation scans of the abdomen of a mother (left panel) and child (right panel) after intravenous injection with radioactive colloidal gold. The large irregularly shaped organ to the left is the liver, which is seen in both panels.

Many families of receptor proteins contribute to the recognition of pathogens in the innate immune response. They are of several different structural types and bind to chemically diverse ligands: peptides, proteins, glycoproteins, proteoglycans, peptidoglycan, carbohydrates, glycolipids, phospholipids, and nucleic acids. 6 Immune defense involves recognition of pathogens followed by their destruction. Almost all components of the immune system contribute to mechanisms for either recognizing pathogens or destroying pathogens, or to mechanisms for communicating between these two activities.

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Advances in Immunology, Vol. 52 by Frank J. Dixon (Ed.)


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