By Sudarshan K. Malhotra
A part of a chain which goals to hide contemporary wisdom within the box of neural technology, this quantity discusses such issues as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in constructing mammals; and improvement of the mammalian auditory hindbrain.
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Extra info for Advances in Neural Science, Volume 2 (Advances in Neural Science)
1984) have reported a high incidence of colocalization of SRIF and NPY in the rat and human neocortex, whereas few cells in the arcuate nucleus contain both peptides. McDonald (1989) found extensive colocalization of SRIF and NPY in all of the amygdaloid nuclei, with the exception ofthe intercalated nucleus and the lateral subdivision of the central nucleus. In contrast, he found no colocalization of SRIF and NPY. Coexistence of NPY and VIP has been found in the guinea pig in non-noradrenergic axons innervating cerebral arteries (Gibbins and Morris, 1988).
1984) have suggested that the VIP effects are mediated by adenylate cyclase activation. As we discussed earlier, considerable information concerning ontogenetic aspects of neuropeptide receptors has derived from in culture studies of CNS tissue. Hosli and Hosli (1989) have described binding sites for VIP using autoradiography in explant cultures of rat spinal cord, brainstem, cerebellum, and cortex. In addition to neurons, binding sites are also observed on astrocytes. Labeling of astrocytes is more intense in spinal cord and brainstem than in cultures of cerebellum and cortex, suggesting a different functional role of astrocytes in the different CNS areas.
They conclude that in late pregnancy and lactation the expression of both neuropeptide genes is stimulated in parallel by mechanisms Neuropeptides in Development 19 operating at a pretranslational level, involving increased gene transcription or mRNA stabilization or both. , 1986). A decrease in this particular class of steroid (after adrenalectomy) appears to increase the potential for altering the expression of the propressophysin gene within this nucleus. , 1988) found that adrenalectomyinduced plasticity in VP expression is further enhanced by ablation of a specific afferent pathway.
Advances in Neural Science, Volume 2 (Advances in Neural Science) by Sudarshan K. Malhotra