By Silvio Garattini
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Additional resources for Advances in Pharmacology and Chemotherapy Volume 17
They should be comparative in nature, using as many commercially available anticoccidials and species of coccidia as possible, and should generate dose-response data for the compound under investigation. Studies on the development of drug resistance, the type of activity of the compound under investigation, and the point in the life cycle at which it acts should be carried out in chickens, but particular facets of these studies may be confirmed or more conveniently carried out in cell culture or embryos.
Experimentally this system may have advantages in cutting down possibilities of cross-contamination in the laboratory, but results obtained are even more difficult to extrapolate to a field situation than ones obtained in laboratory chickens. An embryo-adapted strain of E. tenella has been used in some of these resistance studies, being especially convenient because of enhanced oocyst yields at passage, but as this adapted strain is not generally available and adaptation cannot readily be achieved with one’s own strains, the idea is not of practical significance.
A . Alterations to the C(9) - N(10) Bridge Region B. Alterations to the Glutamate Side Chain . C . Macromolecular Complexes of Methotrexate V . Folate Biochemistry . . . . . A . Relevance to Pharmacology . . . B . FolateTransport . . . . . C . Alteration to the Rate of DHFR Synthesis . D. R-Plasmid Enzyme . . . . . E . Enzyme Polymorphism . . . . F . Folate-Binding Proteins . . . . VI . Antifolate Phannncology . . . . . A . General . . . . . . . B . Conclusions .
Advances in Pharmacology and Chemotherapy Volume 17 by Silvio Garattini