New PDF release: Advances in Vascular Medicine

By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

ISBN-10: 1848826362

ISBN-13: 9781848826366

Understanding the numerous advanced mobile and molecular mechanisms underlying human vascular ailments is key in bettering the administration of sufferers with this clinically vital and wide-ranging team of ailments. this is often quite vital whilst contemplating the level of this factor around the world.

Written by way of a crew of world-renowned professionals, Advances in Vascular Medicine highlights a number of the relationships among uncomplicated technological know-how and scientific drugs, and studies either examine and scientific perform tools and results in vascular biology and pathobiology. it really is an authoritative reference for those vital themes of vascular biology and contains chapters that designate the scientific concerns to the elemental scientist in addition to delivering clinicians with a systematic grounding in vascular ailments. even though there's nonetheless a lot paintings to be performed to improve knowing of vascular disorder, the data and insights contained during this booklet are a necessary contribution to the literature, giving scientists and clinicians the chance to benefit extra approximately this fascinating box of biomedicine.

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Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. J Clin Invest. 1980;66:892–900. 17. Calabresi L, Sirtori CR, Paoletti R, Franceschini G. Recombinant apolipoprotein A-IMilano for the treatment of cardiovascular diseases. Curr Atheroscler Rep. 2006;8:163–167. 18. Favari E, Gomaraschi M, Zanotti I, et al. A unique protease-sensitive high density lipoprotein particle containing the apolipoprotein A-I(Milano) dimer effectively promotes ATP-binding cassette A1-mediated cell cholesterol efflux.

14. Ng DS, Leiter LA, Vezina C, Connelly PW, Hegele RA. Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia. J Clin Invest. 1994;93:223–229. 15. Dastani Z, Dangoisse C, Boucher B, et al. A novel nonsense apolipoprotein A-I mutation (apoA-I(E136X)) causes low HDL cholesterol in French Canadians. Atherosclerosis. 2006;185:127–136. Franceschini G, Sirtori CR, Capurso A, Weisgraber KH, Mahley RW. A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.

However, ex vivo approaches are limited to largely invasive surgical procedures and to tissues and cells that can easily be removed from the body and then reimplanted. Thus, its clinical applications are severely limited. In vivo gene delivery may be able to help overcome this limitation, although faces many challenges of its own. For in vivo gene delivery, the vector is either administered directly into diseased tissue within a patient, or is systemically delivered and targeted to the site of action by the vector.

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Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

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