Get Allogeneic Immunotherapy for Malignant Diseases (Basic and PDF

By John Barrett, Yin-Zhen Jiang

ISBN-10: 0585392218

ISBN-13: 9780585392219

ISBN-10: 0824767810

ISBN-13: 9780824767815

This crucial reference deals a entire assessment of the graft-versus-leukemia (GVL) or -tumor (GVT) influence following allogeneic stem telephone transplantation and lymphocyte transfusion, overlaying a variety of issues from alloimmune responses to scientific functions of GVL, and offering the fundamentals to appreciate the mechanisms of the GVL impact whereas demonstrating tools that use the GVL impression to healing a better variety of melanoma sufferers. provides initial information aiding the concept allogeneic mobilephone remedy can be utilized not just for the remedy of leukemia but additionally for metastatic good tumors! Written by means of over forty international well known specialists within the box and containing greater than 1450 references for in-depth exploration of the topic, Allogeneic Immunotherapy for Malignant ailments ·investigates the capability of the donor-and the host-to wreck residual leukemia cells by means of allogeneic immune response ·determines the right way to direct immune reactions opposed to hematopoietic malignancies appropriately ·reveals which different malignant stipulations will be aware of allogeneic-mediated graft-versus-tumor reactions ·covers the mechanisms that give a contribution to the improvement of responses to minor histocompatibility complicated (mHC) molecules ·focuses at the biology of effector cells and their position in mediating GVL reactions in power myeloid leukemia (CML) ·summarizes the putative influence of human mHag at the GVL impression in bone marrow transplantation (BMT) ·addresses the capability and barriers of oncogene-based immunotherapy ·examines how one can isolate and keep an eye on the GVL component to allograft immunity ·discusses efforts to boost particular anti-leukemic T-cell immunotherapy ·and extra! Attributing the healing influence of allogeneic stem mobile transplantation to the GVL or GVT impression, Allogeneic Immunotherapy for Malignant ailments is an critical reference for hematologists, scientific oncologists, immunologists and researchers within the fields of tumor immunology and melanoma immunotherapy, internists, citizens, and clinical institution scholars in those disciplines.

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Additional info for Allogeneic Immunotherapy for Malignant Diseases (Basic and Clinical Oncology)

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93. Sclmnrich G, Momburg Hanunerling GJ, Arnold B. Anergy induced by thymic medullary epithelium. ELI^ J Inmuno1 1992; 22: 1687- 1691. 94.. Zinkernagel RM, Althagc A. Callahan Welsh RMJr. On the immu~locompetel~ce of H-2incompatibleirradiationbonemarrowchimeras. J Imrnunol1980;124: 2356-2365. 9s. Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984; 307: 168- 170. 96. Barber WH, Mankin JA, Laskow DA, Deicrhoi MH, Julian BA, Curtis JJ, Diethelm AG.

The cellular and molecular basis for the recognition of alloantigens has only recently become clear, as in~ormation regardingM C and T-cell receptor (TCR) structure andftmction has become available. The mechanisms that contribute to the development of an alloresponse and the responses to minor histocorupatibility complex (mHC) molecules are the subjects of this chapter. In addition, strategies to subvertthe mechanisms of self-tolerance in order to induce tolerance to transplanted tissues will be discussed.

Zinkernagel RM, Doherty PC. The discovery of MHC restriction. 11~~mul~ol Today 1997;18:14--17. ~ ~ ~ ~ ~ ~ ~ u nsurveillance o l o g i c a l against altered selfcom5. Zinkernagel RM, Doherty PC. Nature 1974; 25 :547-548. of 6. Bevan MJ. High determinant density may explain the phenomellonalloreactivity. Immunol Today 1984; 5: 128- 130. 7. MatzingerP,Bevan MJ. Hypothesis:whydo so manylymphocytesrespond to major histo~olnpatibilityantigens? Cell Inlmunol 1977; 29: 1-5. 8. Ajitkumar P, GeierSS, Kesari Borriello F, Nakagawa M, Bluestone JA, Saper MA, Wiley DC, Nathenson SG.

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Allogeneic Immunotherapy for Malignant Diseases (Basic and Clinical Oncology) by John Barrett, Yin-Zhen Jiang


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