By Andrew Eisen, Charles Krieger
Amyotrophic Lateral Sclerosis, in a different way referred to as Lou Gehrig's sickness, is one of the degenerative illnesses of the getting older anxious process. this article smartly synthesizes the new explosion of study into this actual situation to build an in depth and accomplished review. Drs. Eisen and Krieger convey their examine services and large scientific event to supply this functional and thought-provoking account. Chapters hide the epidemiology, molecular biology, and pathophysiology of ALS, in addition to concerns pertinent to scientific overview and care.
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Additional info for Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice
6. Relationship between the incidence of ALS per 100000 population and the latitude in degrees north. The data are derived from epidemiological studies in the literature that were considered to have near-complete ascertainment. The incidence of ALS is significantly higher in northern climes. 001). calculation of the regression slope obtained from data points using TQNE and other scales. However, to construct and calculate the slope of the regression line which is used to determine the length of survival of an individual, two or more data points must be acquired over several months.
This particular mutation is the only homozygous mutation associated with familial ALS and has a recessive inheritance. , 1996). Cu/Zn-SOD mutations have not been found in the ALS-Parkinson-dementia complex of Guam, or familial or sporadic PD. The Ala4Val mutation has been the most commonly reported but it is restricted to North America. 4 years (see Fig. , 1997). 3 years, much more like sporadic ALS. The GlulOOGly and the Ilell3Thr mutations have been found widely (in the UK, North America, Australia and New Zealand).
4 Percentile After Eisen et al (1993c). 2). Even though disease duration in young women also appears longer than in other age groups, the numbers were too few for the difference to reach statistical significance. 2 shows that the differences in survival are significantly affected by age but not by sex. 02). 0001). 001). 008). 14 Epidemiological considerations Risk factors for developing ALS Age and gender are the only indisputable risk factors for sporadic ALS (Nelson, 1996). With the growth of an ageing population, it can be predicted that the incidence of ALS and other neurodegenerative diseases will significantly increase.
Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice by Andrew Eisen, Charles Krieger