By M. Petrovic, et al.,
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Extra resources for Analysis, Fate and Removal of Pharmaceuticals in the Water Cycle [Comp Anal Chem Vol 50]
Dermally applied drugs, such as topical antibiotics and hormones); even systemic drugs can be excreted through the skin, an example being the appearance of loratadine on the skin 40 min after ingesting a 10-mg oral dose of the antihistamine . With respect to excretion, these residues are associated primarily with the feces and urine (the relative partitioning between which depends on the pharmacokinetics of the individual drug), and less so via sweat, vomitus, and saliva. , via microbial deglucuronidation via b-glucuronidase ).
A compilation of research needs relevant to all the aspects of PPCPs as pollutants is available . 1 Sources: general considerations Several dimensions define the scope of sources of PPCPs in the environment. As with most chemicals, PPCPs can find their way to the major compartments, including: (i) water (both ground and surface waters—lakes, rivers, streams, marine), (ii) solids (sediments and soils, including agricultural lands), (iii) air, and (iv) biota. , medicated feed dusts used in confined animal feeding operations).
Medicated feed dusts used in confined animal feeding operations). Important to note is that both spatial and temporal dimensions exist for all sources. , excretion of a particular drug by significant portions of the local population), depending on the time scale of measurement, but nonetheless influenced by diurnal and seasonal patterns; an example of the occurrence of transient concentrations is shown by Lissemore et al. . , grab samples) will be representative or whether time-and-space ‘‘integrative’’ sampling is required .
Analysis, Fate and Removal of Pharmaceuticals in the Water Cycle [Comp Anal Chem Vol 50] by M. Petrovic, et al.,